In July 2021, the Canadian Partnership Against Cancer organized a virtual roundtable discussion with First Nations, Inuit and Métis Elders, Knowledge Carriers, community health professionals and researchers—all of whom have experience and knowledge of Indigenous approaches to palliative and end-of-life care. Beginning the journey into the spirit world: First Nations, Inuit and Métis approaches to palliative and end-of-life care in Canada is a foundational background document that was created in response to the meeting recommendations. With the goal of improving informed decision-making and fully recognizing Indigenous approaches to palliative and end-of-life care, participants will be able to highlight 3 keys points from the report including: -listing and discussing factors contributing to First Nations, Inuit and Métis palliative and end-of-life care experiences. -identifying areas for action in palliative and end-of-life care based on priorities, gaps, challenges and needs expressed by First Nations, Inuit and Métis Peoples and communities; -identifying innovative and Indigenous community-based models of care and person-centred approaches to palliative and end-of-life care promising practices, resources and strategies.